Stem Cells are found basically everywhere in our body. But in certain places, these cells are more concentrated and offer a healing potential unlike any man made pharmaceutical or device. The stem cells are harvested from two main areas, from our bone marrow and from our adipose (fat). Depending on the injury or condition you have, stem cells from bone marrow or adipose might be included in your treatment plan.
Bone marrow cells reside deep inside bone cavities in the most protected part of the body and are redundant throughout the organism. This preferential status reflects the primary role these cells play in the survival of the organism.
Tissue repair is a dynamic self-organizing process that relies on cell mobility and growth factor production from cells within a biologic scaffold.
Platelets and Cells from Peripheral Blood Initiate the Inflammatory Process of the Healing Cascade and release cytokines to cause marrow cells to mobilize and home to the injury site (vasculogenesis).
Marrow stem cell and marrow complimentary cell mediated vasculogenesis and cell-to-cell contact with immune system stem cells transition the Healing Cascade from the inflammatory phase to the proliferation and remodeling phase.
Adipose is used in regenerative medicine procedures because mesenchymal stem cells can be isolated from almost every tissue in the human body. The central connecting aspect to explain this fact is that all of these tissues are vascularized and that every blood vessel in the body has mesenchymal cells in abluminal locations. These perivascular cells can be summarily called Pericytes.
Adipose-Derived MSCs are being used therapeutically because they undergo homing to sites of inflammation or tissue injury and they secrete massive levels of bioactive agents that are both immunomodulatory and trophic.
Concentrated Bone Marrow is designed to provide
significant concentrations of CFU-F, CD34+, and total nucleated cell counts. CD34+ are cell markers for hematopoietic stem cells. These are the primary
multipotent cells that replenishes all blood cell types. These cells are crucial for the regenerative processes needed for active tissue repair. In addition to these cells are CFU-F, which are representative of mesenchymal stem cells.
Mesenchymal stem cells (MSC) are multipotent stromal cells that can differentiate into a variety of cell types, including cartilage, bone and adipose cells. BMC provides therapeutic concentrations of these cell types which is the key to desirable patient outcomes.